Ordering Schedule I and II Controlled Substances Using DEA Form 222; Technical Amendments
DEA updates Form 222 to a single-sheet format for ordering Schedule I and II controlled substances; technical amendments effective April 20, 2026.
Aforeworn detected this change in the Pharmacy & Controlled Substances space on July 30, 2026 and published this briefing so affected operators are forewarned rather than caught off guard. It is rated Medium urgency. All pharmacies and registrants that order Schedule I or II controlled substances using DEA Form 222. should confirm how it applies to their specific situation before acting. There is a time constraint attached: April 20, 2026 (effective date of the rule).. Acting after that point can mean penalties, a lapsed licence, or lost eligibility — exactly the kind of surprise Aforeworn exists to prevent. Aforeworn monitors Pharmacy & Controlled Substances continuously and turns every detected change into a plain-English briefing like this one, so you always know first. Forewarned is forearmed.
What changed
DEA Form 222 is now a single-sheet format instead of the previous multi-part form; technical amendments to ordering procedures.
Who it affects
All pharmacies and registrants that order Schedule I or II controlled substances using DEA Form 222.
What you must do
Use the new single-sheet Form 222 for all orders of Schedule I and II controlled substances starting April 20, 2026.
Deadline
April 20, 2026 (effective date of the rule).
Never miss a change like this again
Aforeworn watches Pharmacy & Controlled Substances around the clock and alerts you the moment a rule moves — with a plain-English brief on what to do.
Start your free trialRelated changes in Pharmacy & Controlled Substances
- New Maine law increases access to birth control at pharmacies - WGME
- Andrew Jonathan Morgan: Final Debarment Order
- SpecGx LLC; Withdrawal of Approval of Abbreviated New Drug Application for Methylphenidate Hydrochloride Extended-Release Tablets, 27 Milligrams, 36 Milligrams, and 54 Milligrams
- Schedules of Controlled Substances: Rescheduling of Marijuana; Withdrawal
- Exempt Chemical Preparations Under the Controlled Substances Act