Schedules of Controlled Substances: Temporary Placement of 5,6-Dichloro Brorphine, 5,6-Dichloro Desmethylchlorphine, N-Propionitrile Chlorphine, and Spirochlorphine in Schedule I of the Controlled Substances Act
DEA temporarily places four new synthetic opioids in Schedule I, making their manufacture, distribution, and possession illegal under federal law.
Aforeworn detected this change in the Pharmacy & Controlled Substances space on August 26, 2026 and published this briefing so affected operators are forewarned rather than caught off guard. It is rated High urgency. All pharmacies, including independent, retail chain, compounding, and long-term-care pharmacies, that handle controlled substances. should confirm how it applies to their specific situation before acting. There is a time constraint attached: Effective immediately upon publication in the Federal Register (temporary scheduling order).. Acting after that point can mean penalties, a lapsed licence, or lost eligibility — exactly the kind of surprise Aforeworn exists to prevent. Aforeworn monitors Pharmacy & Controlled Substances continuously and turns every detected change into a plain-English briefing like this one, so you always know first. Forewarned is forearmed.
What changed
Four new substances (5,6-Dichloro Brorphine, 5,6-Dichloro Desmethylchlorphine, N-Propionitrile Chlorphine, and Spirochlorphine) are now temporarily placed in Schedule I of the Controlled Substances Act, making them illegal to handle without DEA authorization.
Who it affects
All pharmacies, including independent, retail chain, compounding, and long-term-care pharmacies, that handle controlled substances.
What you must do
Review current inventory and supply chains to ensure none of these substances are present; if found, contact DEA for guidance on disposal or surrender.
Deadline
Effective immediately upon publication in the Federal Register (temporary scheduling order).
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- International Drug Scheduling; Single Convention on Narcotic Drugs; Convention on Psychotropic Substances; Clobromazolam (Phenazolam); Cychlorphine (N-Propionitrile Chlorphine); Desalkylgidazepam (Bromonordiazepam); Ethylbromazolam; Etomethazene (5-Methyl Etodesnitazene); Spirochlorphine (R6980); Etomidate; Medetomidine; Request for Comments
- PA HB 2749: An Act amending the act of April 14, 1972 (P.L.233, No.64), known as The Controlled Substance, Drug, Device and Cosmetic Act, further providing for drug overdose medication.
- Schedules of Controlled Substances: Placement of Cipepofol in Schedule IV
- Catina Allen, N.P.; Decision and Order
- US-CONGRESS BILLS-119hr10133ih: Fair Prescription Pricing Act of 2026